Ratchet and Clank are known for overpowered weapons, ingenious gadgets, interstellar exploration, and outrageous humor. Ratchet, one of the last Lombaxes in the galaxy, is an impulsive wrench-wielding intergalactic tinkerer and Clank is his logical and witty robotic partner.

With the help of self-proclaimed "hero" Captain Qwark, Ratchet and Clank have defeated many of the universe's most vile villains. In their latest caper, they face an old nemesis, the diabolical Dr. Nefarious, who seeks to control time. After Clank's disappearance, Ratchet races to rescue his best friend. As they attempt to reunite and save the universe they discover that Clank's capture is just the beginning of Nefarious's latest diabolical plot.